格雷夫斯轨道病的临床表现的时间趋势:单中心回顾性研究
R Le Moli1, A Naselli2, F Lo Giudice2
1Department of Clinical and Experimental Medicine, Endocrinology Unit, Garibaldi Nesima Hospital, University of Catania, Via Palermo 636, 95125, Catania, Italy. rlemoli@unict.it.
Journal of endocrinological investigation
|March 15, 2024
概括
格雷夫斯眼病 (GO) 的严重程度在十年内显著下降. 从GO诊断到治疗的时间较长预测了更糟糕的结果,强调了对这种自身免疫性甲状腺眼病及时干预的需要.
科学领域:
- 内分泌学 在内分泌学.
- 眼科医生 眼科 眼科
- 自免疫性疾病 自免疫性疾病
背景情况:
- 格雷夫斯眼病 (GO) 是一种影响轨道组织的自身免疫性疾病,是格雷夫斯病 (GD) 的常见甲状腺外表现.
- 最近的欧洲研究表明,新诊断的患者的GO趋势较轻.
- 缺乏关于GO呈现趋势的当地流行病学数据.
研究的目的:
- 评估10年时间内格雷夫斯眼科医症 (GO) 临床表现严重性的趋势.
- 评估从2005-2006年到2015-2016年在门诊中GO呈现的变化.
- 为了确定GO呈现和严重程度的预测因素.
主要方法:
- 一项对55名患者 (2005年至2006年) 和56名患者 (2015年至2016年) 格雷夫斯眼病的比较研究.
- 分析潜在的预测因素,包括甲状腺功能,吸烟,糖尿病,高胆固醇血症,GO诊断到转诊 (TGOD) 的时间,性别和年龄.
- 两组患者之间的GO严重程度和临床活性得分的统计比较.
主要成果:
- 与早期组 (2005-2006) 相比,在后期患者组 (2015-2016) 中,GO的严重程度显著降低 (p=0.04).
- 从GO诊断到转诊 (TGOD) 的时间≥3个月被确定为GO严重程度的独立预测因素 (p=0.01).
- 其他评估的变量没有显示对GO呈现或严重性的独立影响.
结论:
- 在10年的观察期 (2005-2016) 中,格雷夫斯眼病在呈现时的严重程度显著下降.
- 及时转诊到第三级甲状腺中心至关重要,因为TGOD≥3个月独立预测更严重的GO.
- 这些发现有助于了解GO流行病学,并强调迅速管理的重要性.
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