用E/C/F/TAF或B/F/TAF治疗的艾滋病毒感染者之间明显的脂质组概况:一个开放的前性队列研究
Zhikai Wan1, Junwei Su1, Xueling Zhu1
1The Department of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, No. 79 Qingchun Road, Shangcheng District, Hangzhou, Zhejiang, China.
Infectious diseases and therapy
|March 15, 2024
概括
在艾滋病毒患者中,从埃尔维特格拉维尔/科比西斯塔特/埃姆特里西塔宾/特诺福维尔阿拉芬胺 (E/C/F/TAF) 转换为比克特格拉维尔/埃姆特里西塔宾/特诺福维尔阿拉芬胺 (B/F/TAF),通过改善脂质谱和减少有害的脂质物种,降低了心血管疾病的风险.
科学领域:
- 心血管健康 心血管健康
- 艾滋病毒治疗药物 艾滋病治疗药物
- 利皮多米克 (Lipidomics) 是一种消化剂.
背景情况:
- 在艾滋病毒治疗中,埃尔维特格拉维尔/科比斯塔特/埃姆特里西塔宾/特诺福维尔阿拉芬胺 (E/C/F/TAF) 正被比克特格拉维尔/埃姆特里西塔宾/特诺福维尔阿拉芬胺 (B/F/TAF) 取代.
- 这种切换对血脂和脂质组状况的影响还不清楚.
- 了解这些变化对于评估HIV感染者心血管疾病 (CVD) 风险至关重要.
研究的目的:
- 研究从E/C/F/TAF转换为B/F/TAF对艾滋病毒感染患者的血脂水平和脂质组状况的影响.
- 评估药物转换后特定脂类物种与心血管风险评分之间的关联.
- 为了比较与两种抗逆转录病毒疗法相关的CVD风险概况.
主要方法:
- 对E/C/F/TAF的HIV患者进行前性研究,其中一些人转向B/F/TAF.
- 在基线,12周和24周收集临床数据和血液样本.
- 使用液体染色学-质谱学 (LC-MS) 的脂质组分析和评估心血管风险得分.
主要成果:
- 转换为B/F/TAF的患者在24周内显示出明显较低的甘油三和非常低密度脂蛋白胆固醇水平,与那些仍在使用E/C/F/TAF的患者相比.
- 在B/F/TAF组中观察到弗雷明汉风险评分 (FRS) 的小但显著下降.
- E/C/F/TAF增加了特定的二甲化物 (DGs),三甲化物 (TAGs) 和酸胆 (LPCs) 的水平;切换到B/F/TAF增加了脂和糖脂,一些DG和TAG物种与更高的FRS相关.
结论:
- 埃尔维特格拉维尔/科比西斯塔特/埃姆特里丁/特诺福维尔阿拉芬胺 (E/C/F/TAF) 与与艾滋病毒感染者心血管疾病 (CVD) 风险增加相关的脂类物种的积累有关.
- 比克特格拉维尔/emtricitabine/tenofovir alafenamide (B/F/TAF) 显示对心血管疾病相关的脂质配置文件的影响有所减少.
- 切换到B/F/TAF与艾滋病毒感染者的整体心血管疾病风险概况较低有关.
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