鉴定亨廷顿病患者最大运动测试对心率变化反应的特征
Haoyu Li1, Radhika Desai2, Norberto Quiles3
1Programs in Physical Therapy, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.
患有亨廷顿病 (HD) 的人表现出运动能力降低和自主神经系统功能障碍,影响心率变化 (HRV) 在休息和恢复期间. 对于患有HD的人来说,建议修改炼处方.
科学领域:
- 心血管生理学心血管生理学
- 神经退行性疾病 神经退行性疾病
- 自主神经系统功能 自主神经系统功能
背景情况:
- 亨廷顿病 (HD) 是一种神经退行性疾病,其特征是自主神经系统 (ANS) 功能障碍.
- 心率变化 (HRV) 作为一个非侵入性指标,对ANS功能.
- 之前的研究还没有研究HD患者对运动的HRV反应.
研究的目的:
- 在运动期间对患有HD的个体进行HRV的表征.
- 探索这些研究结果对HD的运动处方的影响.
- 为了调查HD心脏dysautonomia的机制.
主要方法:
- 从PACE-HD研究中招募了19名患有HD的参与者和13名年龄/性别匹配的对照.
- 使用极地H10监测器测量HRV,在分级循环-人体运动计测试之前,期间和之后测量.
- 分析的HRV参数,包括RMSSD,SDSD,LF,HF和HF/LF比率.
主要成果:
- 与对照组相比,患有HD的参与者心率峰值和心率储备较低.
- 在HD组中观察到休息时HRV参数 (RMSSD,SDSD) 降低.
- 在LF,HF (nu),LF (nu) 和HF/LF比率的显著差异表明,在运动和恢复期间,在HD中表现出交感血管失调.
结论:
- 患有HD的个体表现出有氧运动能力降低和交感血管功能失调.
- 自主功能障碍存在于休息状态和在HD的运动后恢复期间.
- 修改运动处方和进一步研究HD中心脏dysautonomia机制是有必要的.
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