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Updated: Jun 30, 2025

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通过抑制巨细胞中MHCII类机械,PAD4控制瘤免疫力

Michael R Pitter1, Ilona Kryczek2, Hongjuan Zhang2

  • 1Department of Surgery, University of Michigan Medical School, Ann Arbor, MI, USA; Center of Excellence for Cancer Immunology and Immunotherapy, Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA; Graduate Program in Molecular and Cellular Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.

Cell reports
|March 15, 2024
PubMed
概括

在与瘤相关的巨细胞 (TAMs) 中的丁氨酸减弱酶4 (PAD4) 阻碍了抗癌免疫力. 抑制PAD4可以增强T细胞的反应,改善免疫治疗的结果.

关键词:
CP: 癌症 癌症 癌症CP: 免疫学 免疫学在MHC中,MHC是最重要的.在PAD4中使用PAD4.饼是为了饼.美国国家统计局 (STAT1)一个T细胞细胞.抗原呈现的呈现方式.检查站检查站检查站检查站检查站检查站素化是指素化.免疫疗法 免疫疗法巨细胞是一个巨细胞.瘤是一个瘤.

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