严重精神疾病与肺癌风险之间的因果关系
Xiaohan Chen1, Shudan Wang, Weiyu Shen
1The Affiliated Lihuili Hospital, Ningbo University, Ningbo, China.
Medicine
|March 15, 2024
概括
严重的精神疾病 (SMI) 会增加肺癌 (LC) 的风险,特别是精神分裂症. 吸烟和酒精调解了这种联系,强调了在精神分裂症患者中进行LC查的必要性.
科学领域:
- 精神病学和瘤学的精神病学和瘤学
- 遗传流行病学遗传流行病学
背景情况:
- 观察性研究表明,严重精神疾病 (SMI) 和肺癌 (LC) 风险之间存在联系.
- SMI和LC之间的因果关系仍未确立,需要进一步调查.
研究的目的:
- 使用孟德尔随机化 (MR) 调查SMI对LC风险的病因影响.
- 量化SMI-LC关系中可修改的风险因素的调解效应.
主要方法:
- 两个样本和两个步骤的孟德尔随机化 (MR) 分析.
- 使用了精神分裂症,主要抑郁症 (MDD) 和双相情感障碍 (BD) 的总结级数据,这些数据来自精神病基因组学联盟 (PGC).
- 采用逆方差加权 (IVW) 方法进行因果估计,并进行敏感性分析.
主要成果:
- 精神分裂症被确定为肺癌 (LC) 的重要危险因素 (OR=1.06,P=3.48E-03).
- 大型抑郁症 (MDD) 和双相情感障碍 (BD) 与LC风险没有显著关联.
- 在精神分裂症-LC风险关联中,吸烟占24.66%,酒精消费占7.59%.
结论:
- 精神分裂症与肺癌 (LC) 的风险增加有因果关系.
- 吸烟和饮酒是精神分裂症和LC之间的因果途径中的重要调解因素.
- 对于精神分裂症患者,特别是那些有吸烟和饮酒史的人,建议加强LC查.
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