亚thalamic区域的地形解剖学,特别感兴趣的是人类中枢前脑捆绑
Cintia Meszaros1, Peter Kurucz2,3, Gabor Baksa1
11Department of Anatomy, Semmelweis University, Budapest, Hungary.
Journal of neurosurgery
|March 15, 2024
概括
轨道图学研究表明,中间前脑束 (MFB) 是大脑深层刺激的目标. 然而,解剖学剖析揭示了它.
科学领域:
- 神经解剖学是一个神经解剖学.
- 神经外科 神经外科
- 神经成像是一种神经成像.
背景情况:
- 中间前脑束 (MFB) 被提议作为深度大脑刺激 (DBS) 对情绪障碍的目标,基于路径学表明其通过亚thalamic区域的过程.
- 在帕金森病患者的亚thalamic核 (STN) DBS期间的低迷症与MFB刺激有关,需要对MFB的过程进行解剖验证.
- 现有的MFB精确轨迹的解剖学描述,特别是在STN周围,仍然没有通过直接解剖学方法得到证实.
研究的目的:
- 在解剖学上验证中枢前脑束 (MFB) 通过下丘脑区域的过程.
- 详细描述围绕着亚thalamic核 (STN) 的纤维通道.
- 为了澄清STN DBS期间观察到的副作用的解剖学基础.
主要方法:
- 使用克林格勒方法对19个人类半球进行剖析,并用神经纤维银浸的一个半球进行组织学检查.
- 100名健康受试者 (200个半球) 中MFB的轨道图重建,来自人类连接体项目S500发布.
- 宏观剖析和组织学发现与轨迹学结果的相关性.
主要成果:
- 剖析揭示了STN附近的白质区域,包括安萨眼,眼,乳头眼,小脑纤维和中间眼.
- 通过解剖学剖析无法识别出与MFB相对应的明显纤维束,正如通过通道图所描绘的那样.
- 研究人员发现,MFB的轨道图谱简化描绘高度依赖于所选择的值参数.
结论:
- 在路谱学中代表MFB的流线可能是由于扩散权重MRI纤维跟踪方法的局限性造成的.
- 这些流线似乎代表着亚thalamic纤维束,特别是 ansa lenticularis 和 lenticular fasciculus,被错误地归因为MFB.
- 这些纤维捆绑错误地继续进入内部囊的前肢,朝着前额皮层,而不是在体下区域形成明显的MFB.
关键词:
人体解剖学 解剖学 解剖学深度大脑刺激 刺激大脑纤维解剖 纤维解剖 纤维解剖功能神经外科 功能神经外科中部前脑束中部前脑束亚太lamus 亚太lamus 亚太lamus 亚太lamus 是一个路径学 路径学 路径学 路径学 路径学更多相关视频
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