在大气压场脱吸质谱学中用于发射器定位,观测和加热的坚固多功能组件
Jan Schweinfurth1, H Bernhard Linden2, Jürgen H Gross3
1Institute of Inorganic Chemistry, Heidelberg University, Heidelberg, Germany.
European journal of mass spectrometry (Chichester, England)
|March 15, 2024
概括
一个新的设备增强了大气压场脱吸 (APFD) 质谱 (MS) 以实现更快,可重复的分析. 这种设置可以改善使用发射器加热的各种化合物的离子生成和信号噪声比.
科学领域:
- 分析化学 分析化学
- 质谱测量质量谱测量
背景情况:
- 大气压场绝吸法 (APFD) 质谱法 (MS) 是一种新的场绝吸法 (FD) 变体.
- APFD旨在将FD-MS特性与大气压 (AP) 接口相结合.
- 之前的APFD证明了极性,离子和多环芳香化合物的离子生成.
研究的目的:
- 在APFD-MS中描述一个定制的设备,用于改进样品加载和发射器定位.
- 包括用于发射器观测和电阻加热的功能.
- 为了提高APFD-MS操作的稳定性,可靠性和多功能性.
主要方法:
- 开发了一种定制设备,用于在质谱仪的AP接口上精确地加载和定位场发射器.
- 该设备包括实时发射器观测和受控电阻加热的能力.
- 该设置使用里埃变态离子循环子共振 (FT-ICR) 和被困离子移动四极飞行时间 (TIMS-Q-TOF) 仪器进行了测试.
主要成果:
- 定制设备可以实现更快,更可重复的样本加载和发射器定位.
- 电阻发射器加热加速了分析物的脱离,并允许更高分子量化合物的电离.
- 由于来自压缩光谱采集周期的较高离子电流,观察到信号噪声比率的改善.
结论:
- 开发的设备显著提高APFD-MS的操作能力,确保强大可靠的性能.
- 发射器加热对于扩大可检测分析物的范围和提高光谱质量至关重要.
- 多功能设计允许与不同质谱平台集成,扩大APFD-MS的适用性.
相关概念视频
01:22Atomic Emission Spectroscopy: Instrumentation
379
The instrumentation of atomic emission spectrometry (AES) involves various components, including atomization devices that convert samples into gas-phase atoms and ions. There are two main types of atomization devices: continuous and discrete atomizers. Continuous atomizers, like plasmas and flames, introduce samples in a constant stream, while discrete atomizers inject individual samples using syringes or autosamplers. The most common discrete atomizer is the electrothermal atomizer.
379
01:25Atomic Absorption Spectroscopy: Atomization Methods
421
Atomic Absorption Spectroscopy (AAS) atomizes samples through flame atomization or electrothermal atomization. Flame atomization typically involves a nebulizer and spray chamber assembly to combine the sample with a fuel–oxidant mixture, creating a fine aerosol mist that enters a burner. Typically, the fuel and oxidant are combined in an approximately stoichiometric ratio. However, for atoms that are easily oxidized, a fuel-rich mixture may be more advantageous. Only about 5% of the...
421
01:20Atomic Emission Spectroscopy: Overview
2.1K
Atomic emission spectroscopy (AES) is an analytical technique used to determine the elemental composition of a sample by analyzing the light emitted from excited atoms. In AES, atoms in a sample are excited to higher energy levels by thermal energy from high-temperature sources, such as plasma, arcs, or sparks. When these excited atoms return to lower energy states, they emit light at specific wavelengths characteristic of each element. The resulting atomic emission spectrum, which consists of...
2.1K
01:29Atomic Emission Spectroscopy: Lab
161
AES is a powerful analytical technique, especially effective when used with plasma sources, producing abundant spectra in characteristic emission lines. The Inductively Coupled Plasma (ICP), in particular, yields superior quantitative analytical data due to its high stability, low noise, low background, and minimal interferences under optimal experimental conditions. However, newer air-operated microwave sources are emerging as promising alternatives that could be more cost-effective than...
161
01:19Inductively Coupled Plasma Atomic Emission Spectroscopy: Principle
608
Inductively coupled plasma (ICP) is the most widely used plasma source in atomic emission spectroscopy (AES), also known as Inductively Coupled Plasma Optical Emission Spectroscopy (ICP-OES). The ICP source, or torch, consists of three concentric quartz tubes with argon gas flowing through them. A spark from a Tesla coil initiates the ionization of argon, generating a high-temperature plasma.
The ions and electrons produced interact with the fluctuating magnetic field created by a water-cooled...
The ions and electrons produced interact with the fluctuating magnetic field created by a water-cooled...
608
01:19Gas Chromatography: Types of Detectors-II
369
In gas chromatography, different detectors are employed to meet specific analytical needs. These detectors are often categorized based on their detection mechanisms and the types of compounds they are best suited to analyze. Thermal Conductivity Detectors (TCD), Flame Ionization Detectors (FID), and Electron Capture Detectors (ECD) represent common categories, each with unique operating principles and applications. However, beyond these, several other detectors are designed for more specialized...
369