玉米寡通过调节Sirtuin信号通路来缓解非酒精性脂肪性肝病
Yali Xu1,2, Ting Su2, Hricha Mishra1
1Laboratory for Cellular Function Conversion Technology, RIKEN Center for Integrative Medical Sciences, Yokohama 2300045, Japan.
Journal of agricultural and food chemistry
|March 15, 2024
概括
玉米寡 (CP) 有效地对抗小鼠的非酒精性脂肪性肝病 (NAFLD) 和非酒精性脂肪性肝炎 (NASH). 这种功能性可以减少体重增加,改善肝酶,调节关键的代谢途径,显示NAFLD治疗的希望.
科学领域:
- 代谢障碍 代谢障碍 代谢障碍
- 肝病学 肝病学是一种肝病学.
- 营养保健品 营养保健品
背景情况:
- 非酒精性脂肪性肝病 (NAFLD) 是最常见的慢性肝病,从简单的脂肪性肝炎到非酒精性脂肪性肝炎 (NASH).
- 玉米寡 (CP) 以其代谢调节功能而闻名.
研究的目的:
- 在小鼠模型中研究CP对饮食引起的脂肪肝病和NASH的保护作用.
- 阐明在NAFLD中CP的作用背后的分子机制.
主要方法:
- 小鼠接受高脂肪饮食 (HFD) 或链毒素/HFD模型来诱导NAFLD和NASH.
- 评估了口服CP对体重,肝酶 (AST,ALT) 和肝病理学的影响.
- 蛋白质组分析被用来识别CP调节的信号通路,包括氧化酸化和Sirtuin (SIRT) 通路.
主要成果:
- 在HFD诱导的脂肪肝模型中,CP显著降低了体重增加,血清胆固醇,AST和ALT水平.
- 在NASH模型中,CP减弱了体重增加,肝损伤,并显示了肝炎和纤维化的一些减少.
- 蛋白质组分析表明,CP调节氧化酸化和SIRT信号传递,特别是抑制肝脏线粒体SIRT3和SIRT5的表达.
结论:
- 玉米寡 (CP) 对代谢压力诱导的NAFLD和NASH进展具有预防作用.
- CP的机制涉及调节氧化应激和SIRT信号通路.
- CP具有作为治疗NAFLD和NASH晚期治疗的治疗剂的潜力.
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