脱氧尼瓦伦醇和烟素使 brojlers 易患细菌性冠状炎与骨髓炎
Khawla Alharbi1, Nnamdi Ekesi2, Amer Hasan3
1Cell and Molecular Biology Program, University of Arkansas, Fayetteville, Arkansas, USA; Department of Poultry Science, University of Arkansas, Fayetteville, Arkansas, USA.
Poultry science
|March 15, 2024
概括
brojiler料中的微毒素,如deoxynivalenol (DON) 和fumonisin (FUM),增加了带有骨髓炎 (BCO) 的细菌性冠状炎的发生率. 这种情况在垃圾床上加剧了,突出显示了受污染的料对肉健康的影响.
科学领域:
- 动物科学动物科学
- 兽医医学 兽医医学 兽医医学
- 毒理学 毒理学 毒理学
背景情况:
- 带有骨髓炎 (BCO) 的细菌性慢性病是全球 brojiler行业的重要动物健康和经济问题.
- 快速生长的肉由于机械压力,细菌转移和骨生长板的殖民,容易受到BCO的感染.
- 在料成分中普遍存在的真菌毒素 (MTX),包括脱氧尼瓦伦醇 (DON) 和烟素 (FUM),可以损害肠道完整性和免疫功能.
研究的目的:
- 调查DON和FUM受污染的料对 brojlers中BCO的发生率的影响.
- 评估地板类型 (电线与垃圾) 对MTX诱导的BCO的影响.
- 探索暴露于MTX的肉中肠道透性和BCO的关系.
主要方法:
- 一个2x2的因数设计研究,涉及720只肉.
- 实验组包括MTX受污染的饮食 (DON和FUM) 和在电线和垃圾地板上的对照饮食.
- 在整个试验中,通过的鸟类尸检来评估的发病率.
主要成果:
- 与对照对象相比,被MTX污染的食养的肉在电线地板 (73.3%对62.0%) 和垃圾地板 (54.0%对34.0%) 上表现出更高的BCO的发病率.
- 在垃圾地板上,MTX 增加了 BCO 发生率,比在电线地板上 (+12%) 更显著 (+20%).
- 在电线地板上的MTX养肉中观察到肠道透性增加,与BCO的相关性.
结论:
- 脱氧尼瓦伦醇 (DON) 和烟素 (FUM) 作为诱导因素,增加肉中BCO发病率.
- 菌毒素污染对肉的健康构成重大风险,特别是当它们在垃圾地板上养时.
- 虽然MTX增加了BCO,但在诱导的饮食类型和地板类型之间没有发现显著的相互作用.
相关概念视频
Bone Disorders
3.5K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.5K
Pneumonia II: Pathophysiology
268
The pathophysiology of pneumonia involves the following steps:
268
Teratogenicity
2.4K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.4K
Necrosis
4.5K
Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
4.5K
Pneumonia III: Complications and Assessment
208
Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
208
Factors Affecting the Risk of Infection
11.8K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
11.8K


