基于Salvia miltiorrhiza Bunge (Danshen) 的纳米输送系统用于抗癌疗法
Yiyang Jia1, Dandan Yao1, Hui Bi1
1Department of Pharmacy, The Air Force Hospital of Eastern Theater Command, Nanjing, 210002, China.
概括
本综述强调了纳米输送系统如何增强Salvia miltiorrhiza (Danshen) 成分的抗瘤作用. 这些系统提高了生物可用性和瘤向性,为基于Danshen的纳米医学的临床应用铺平了道路.
科学领域:
- 药理学和纳米技术的应用
- 自然产品化学 自然产品化学
- 瘤学 治疗学 治疗学
背景情况:
- (Salvia miltiorrhiza) 是一种传统的中国草本,具有重要的心血管,脑血管和抗癌性质.
- 丹申的关键活性成分在癌症治疗中表现有前途,但其生物可用性较差,降解速度较快.
- 现有的局限性阻碍了Danshen的抗瘤化合物的临床疗效.
研究的目的:
- 对丹申的活性成分纳米传递系统的最新进展进行审查.
- 总结克服丹申化合物的药理动力学限制的策略.
- 探索这些增强化合物的应用在抗瘤治疗中.
主要方法:
- 在Embase,谷歌学者,PubMed,Scopus和Web of Science数据库中进行了系统的文献搜索.
- 搜索的术语包括"Danshen"",Salvia miltiorrhiza",特定的活性成分 (例如,Tanshinone,Salvianolic acid),以及"瘤"",分娩"和"纳米药"等概念.
- 收集了截至2023年9月发布的关于抗瘤应用的药物修饰的数据.
主要成果:
- 丹申提取物有效地抑制了瘤细胞的增殖.
- 设计了各种药物输送系统,以提高Danshen成分的抗瘤疗效.
- 策略包括增强生物可用性,瘤向性,生物屏障透性和组合疗法.
结论:
- 系统地审查了用于抗瘤治疗的丹申成分药物修饰的最新进展.
- 已经开发出各种各样的纳米装饰技术.
- 该审查旨在激励进一步开发基于Danshen的纳米交付系统,用于临床翻译.
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