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Updated: Jun 30, 2025

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老年成年女性的萨尔科佩尼亚指数和认知功能之间的相关性:使用NHANES数据的横截面研究
Yajuan Huang1, Rui Zhang1, Xinyang Hong2
1Department of Nephrology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; Key Laboratory of Human Microbiome and Chronic Diseases (Sun Yat-sen University), Ministry of Education, Guangzhou, China; Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
概括
麻症指数 (SI) 可能表明肌肉损失,并与认知能力下降有关. 在正常功能的老年女性中,较高的SI与更好的认知功能相关.
科学领域:
- 老年学是一门学科.
- 神经学 神经学
- 生物标志物 生物标志物
背景情况:
- 标志着肌肉损失的萨科佩尼亚与认知障碍有关.
- 麻症指数 (SI) 显示了作为麻症生物标志物的潜力.
- SI与认知功能之间的关系需要进一步研究.
研究的目的:
- 调查萨科佩尼亚指数 (SI) 与老年人认知功能之间的关联.
- 探索SI作为认知障碍与肌肉健康相关的生物标志物的潜力.
主要方法:
- 利用了美国国家健康和营养检查调查 (NHANES) (1999-2002) 的数据.
- 包括65-80岁的个人,具有可用的SI和认知数据 (DSST) 和GFR≥90.
- 使用血清肌素和细胞素C计算SI;采用多变量建模和三位分类进行分析.
主要成果:
- 在美国老年女性的SI和认知功能得分之间发现了显著的正相关性 (β = 0.160,P = 0.00461).
- 在对女性进行分类分析时,较高的SI与更好的认知功能得分有关 (OR = 3.968,P = 0.00025),经过对混因素进行调整后.
结论:
- 更高的萨科佩尼亚指数与正常功能老年妇女认知障碍的患病率降低有关.
- 在老年人群中,尤其是女性中,SI可以作为认知健康的有用指标.
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