ncRS:在败血症中非编码RNA的资源
Baocai Zhong1, Yongfang Dai1, Li Chen1
1School of Computer and Software, Chengdu Neusoft University, Chengdu, China.
Computers in biology and medicine
|March 15, 2024
概括
本研究介绍了ncRS,这是一个1144个与败血症相关的非编码RNA (ncRNA) 的数据库. 本资源有助于了解败血症的发病因子,并识别用于诊断和个性化治疗的生物标志物.
科学领域:
- 生物化学 生物化学
- 遗传学 遗传学 是一个
- 分子生物学分子生物学
背景情况:
- 败血症是一种具有高死亡率的危及生命的疾病,是由宿主对感染的反应失调所驱动的.
- 鉴定毒症中的关键分子参与者对于改善患者的治疗结果至关重要.
- 非编码RNAs (ncRNAs) 越来越多地被认为是它们在诸如败血症等复杂疾病中的作用.
研究的目的:
- 介绍ncRS数据库,这是对与败血症相关的非编码RNA (ncRNA) 的全面资源.
- 为研究人员和临床医生提供一个工具,以探索cRNA在败血症中的功能.
- 促进新型生物标志物的发现,用于败血症诊断,预后和个性化治疗.
主要方法:
- 策划收集了1144个经过实验验证的ncRNAs,这些ncRNAs与败血症有关.
- 整合来自多个公共数据库的RNA数据,实验证据和注释.
- 在http://www.ncrdb.cn.cn上可访问的ncRS数据库的开发.
主要成果:
- ncRS数据库提供了与败血症相关的ncRNAs的集中存储库.
- 为每个ncRNA提供详细的实验验证和功能注释.
- 能够为败血症研究进行全面的数据检索和分析.
结论:
- ncRS数据库是促进败血症研究的宝贵资源.
- 促进了ncRNA在败血症发病过程中的作用的探索.
- 支持识别潜在的ncRNA生物标志物,以改善败血症管理和个性化医疗.
相关概念视频
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Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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02:39lncRNA - Long Non-coding RNAs
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03:21RNA-seq
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02:24Ribosome Profiling
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01:56Riboswitches
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