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Updated: Jun 30, 2025

From a 2DE-Gel Spot to Protein Function: Lesson Learned From HS1 in Chronic Lymphocytic Leukemia
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向鱼样蛋白 (KLHL):取得的成就,挑战和前景

Yangguo Zhou1, Qiong Zhang1, Ziquan Zhao1

  • 1Jiang Su Key Laboratory of Drug Design and Optimization and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.

European journal of medicinal chemistry
|March 15, 2024
PubMed
概括

凯尔奇样蛋白 (KLHLs) 是细胞过程中的关键适配体. 本综述详细介绍了针对KLHLs的抑制剂,为了解疾病途径和治疗开发提供了洞察力.

关键词:
这就是KLHLs.凯尔奇域是一个凯尔奇域.PPI 抑制剂 PPI 抑制剂这就是PROTAC.在TPD中,TPD是TPD.

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In Situ Monitoring of Transiently Formed Molecular Chaperone Assemblies in Bacteria, Yeast, and Human Cells00:08

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Protein-protein Interfaces02:04

Protein-protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
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