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伊朗多发性硬化症患者的民族差异,基于国家注册的研究

Fereshteh Ashtari¹, Aryan Kavosh², Seyed Mohammad Baghbanian³

¹Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran; Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Clinical neurology and neurosurgery

|March 15, 2024

概括

这项研究揭示了伊朗多发性硬化症 (MS) 人口统计和临床结果的显著种族差异. 了解这些差异对于针对不同种族群体的MS诊断和预后至关重要.

科学领域:

神经学神经学
流行病学流行病学
遗传学是一个遗传学.

背景情况:

历史上,多发性硬化症 (MS) 研究一直专注于西方人群,在了解种族差异方面存在差距.
伊朗在中东地区的MS患病率最高,使其成为基于种族的研究的关键地区.

研究的目的:

调查伊朗主要种族中MS (pwMS) 患者的人口和临床差异.
探索种族在诊断和预后的潜在作用MS在一个国家.

主要方法:

一项横截面研究利用了来自伊朗国家多发性硬化病登记处的数据.
来自六个省的PwMS接受了采访,以确定种族 (波斯人,库尔德人,卢尔人,阿塞拜疆人,阿拉伯人,马赞达拉尼人).
人口和临床特征在各族群之间进行了比较.

主要成果:

在不同种族的发病年龄,年龄分布和诊断年龄方面观察到显著的差异.
现型分布,向二次渐进性多发性硬化症 (SPMS) 的进展和复发率存在显著差异.
库尔德人显示了最高的扩展残疾状态量表 (EDSS) 评分,而卢尔人则是最低的.
波斯人患儿多发性硬化和临床隔离综合征 (CIS) 的比率更高;阿拉伯人患复发性复发性硬化和SPMS的比率更高.

结论:

种族背景影响MS诊断,疾病过程和进展.
波斯人患儿多发性硬化和CIS的比例较高,而库尔德人和卢尔人则表现出不同的EDSS分数和复发率.
在伊朗观察到的种族差异强调了需要在MS管理和研究中采取特定种族的方法.

关键词:

障碍障碍是指残疾人的残疾.疾病进展疾病进展.民族身份民族身份伊朗伊朗伊朗伊朗多发性硬化症是多发性硬化症.

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