慢性炎症性脱髓性多神经病变和HEV抗体状态:意大利拉齐奥的一个病例对照研究
Federica Moret1, Enea Spada2, Marco Ceccanti1
1Department of Human Neuroscience, Centre for Rare Neuromuscular Disease, Sapienza University of Rome, Rome, Italy.
Journal of the neurological sciences
|March 15, 2024
概括
乙型肝炎病毒 (HEV) 感染与慢性炎症性脱线性多基基隆性神经病 (CIDP) 相关. 在CIDP患者中,猪肝香肠的消费和IVIg/SCIg的使用被确定为HEV阳性风险因素.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 传染病与引发慢性炎症性脱叶林性多基基隆性神经病 (CIDP) 有关.
- 已知E型肝炎病毒 (HEV) 与吉林巴雷综合征有关.
研究的目的:
- 调查HEV感染和CIDP之间的关联.
- 在CIDP患者和对照中确定HEV感染的风险因素.
主要方法:
- 一项病例控制研究,涉及82名CIDP患者和260名普通人口对照.
- 血液样本使用ELISA和RT-PCR进行了抗HEVIgG,IgM和RNA的测试.
- 收集了人口统计,病史和HEV风险因素的数据.
主要成果:
- 与对照组 (17.3%) (或3.04) 相比,CIDP患者的抗HEVIgG血清阳性显著更高 (39.0%).
- 多变量分析显示,抗HEV阳性和猪肝香肠的消费 (OR 10.44) 和IVIg/SCIg的使用 (OR 31.32) 之间存在显著的关联.
结论:
- 在CIDP患者中,抗HEV IgG患病率的增加可能与IVIg/SCIg治疗的被动抗体获取有关.
- 接受IVIg/SCIg的CIDP患者报告了HEV风险因素,暗示了潜在的感染.
- 为了证实这些发现,需要对较大的CIDP队列进行进一步的研究,这些队列不接受IVIg/SCIg.
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