系统性皮质类固醇在内脏病治疗中的使用-第二部分:提高局部麻醉的成功率
Norah Alajlan1, Alonso Carrasco-Labra2, Bekir Karabucak3
1Department of Restorative Dental Science, College of Dentistry, King Saud University, Riyadh, Saudi Arabia; Department of Endodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Journal of endodontics
|March 15, 2024
概括
系统性皮质类固醇显著改善了不可逆转的脉炎的麻醉成功. 预防性使用这些抗炎药物可以增强局部麻醉作用,特别是在牙科患者的下膜神经阻塞.
科学领域:
- 牙周内科医院 牙周内科医院 牙周内科医院
- 药理学 药理学是指药理学的学科.
- 麻醉学 麻醉学
背景情况:
- 慢性炎症在不可逆转的胸膜炎导致过敏症,并使局部麻醉复杂化.
- 有效的麻醉对于内牙治疗的成功至关重要.
- 系统性皮质类固醇因其抗炎作用而被探索,以改善麻醉.
研究的目的:
- 系统地审查和分析系统管理的皮质类固醇在增强麻醉成功方面的疗效.
- 为了评估预防性皮质类固醇使用对因不可逆转的胸膜炎而接受内牙治疗的患者的影响.
主要方法:
- 进行全面的数据库搜索 (PubMed,Cochrane,Embase,Scopus等) 和参考检查.
- 用风险比率和随机效应模型评估麻醉成功作为主要结果.
- 使用推,评估,开发和评估 (GRADE) 方法对证据确定性的评估.
主要成果:
- 分析了12项涉及917名参与者的研究.
- 皮质类固醇组显示了显著更高的麻醉成功 (风险比率=1.66,P<.00001).
- 在聚合数据中发现了适度的异质性 (I2 = 57%,P = .007).
结论:
- 中等确定性证据支持预防性系统性皮质类固醇的使用,以改善局部麻醉.
- 这种方法对于不可逆转的脉炎下层气泡神经阻塞特别有效.
- 皮质类固醇为治疗疼痛和改善内牙科治疗结果提供了一个有希望的辅助药物.
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