脊椎病患者癌症风险:基于人口的队列研究
Frederikke S Troelsen1, Dóra K Farkas1, Rune Erichsen2
1Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus N, Denmark.
概括
脊椎病 (DD) 与结直肠外癌症,特别是肺癌和癌的风险更高有关. 患有DD的患者可能由于共同的风险因素而增加了整体癌症风险.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 脊椎病 (DD) 是常见的,并且它与结直肠癌的关联已经确立.
- 然而,DD与其他癌症类型之间的联系不太清楚.
研究的目的:
- 为了调查不同癌症的长期风险,随着分歧疾病的诊断.
- 为了确定分歧性疾病是否与结直肠以外的恶性瘤有关.
主要方法:
- 全国范围,基于人口的队列研究,使用丹麦健康数据 (1978-2019).
- 在诊断后的20年内跟踪了200,639名DD患者.
- 与普通人口相比,癌症发病率的计算标准化发病率比率 (SIRs).
主要成果:
- 在DD患者中观察到总体增加的长期癌症风险 (大多数地点的SIR>1).
- 肺癌,支气管癌和气管癌 (1.20) 和癌 (1.27) 的SIR值升高.
- 结直肠癌的SIR降低 (0.75) 表明监测或保护因素增加.
结论:
- 脊椎病的诊断与患各种癌症的相对风险增加有关.
- 共同的风险因素可能导致DD患者的癌症风险增加.
- 在DD患者中,结肠镜的增加可能解释了结肠直肠癌风险的降低.
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