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在体外外膜氧化模型中减少疏水性药物吸附

Nitish Khurana¹, Kamiya Watkins², Debika Ghatak²

¹Department of Molecular Pharmaceutics, University of Utah, Salt Lake City, UT, USA; Utah Center for Nanomedicine, University of Utah, Salt Lake City, UT, USA; Division of Clinical Pharmacology, Department of Pediatrics, School of Medicine, University of Utah, Salt Lake City, UT, USA.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

|March 15, 2024

概括

在纳米尺度结构中封装像普罗波这样的疏水药物显著减少了它们对体外膜氧化 (ECMO) 电路的吸附. 这种方法可以改善药物输送和重症监护机构患者的治疗结果.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
药理学药理学是指药理学的学科.
关键护理医学关键护理医学

背景情况:

体外膜氧化 (ECMO) 对患有严重心脏和肺衰竭的患者至关重要.
由于药物吸附到电路中,ECMO患者的药物剂量具有挑战性,导致高死亡率.
疏水性药物,如普罗波,对ECMO成分具有显著的吸附.

研究的目的:

开发纳米尺度的propofol输送系统,以最大限度地减少其在ECMO电路中的吸附.
评估这些药物输送系统的稳定性,生物相容性和有效性.

主要方法:

使用块共聚合物和聚乙烯糖醇绑定的脂质体进行囊化.
使用动态光散射和高性能液体染色学 (HPLC) 进行传递系统的表征.
在ECMO模型中对体稳定性,细胞兼容性 (THP-1细胞),补充激活和药物吸附的体外评估.

主要成果:

所有开发的输送系统 (细胞和脂质体) 都表现出七天的体稳定性.
这些系统表现出细胞相容性,并没有激活补充通路.
在体外ECMO模型中,封装显著降低了propofol吸附.

结论:

纳米级封装有效地防止了对ECMO电路的疏水性药物吸附.
这一策略有望改善药物剂量准确性和ECMO治疗中的患者结果.
表面功能化纳米结构为重症监护中的药物输送挑战提供了可行的解决方案.

关键词:

吸附方式吸附方式吸附方式在ECMO中,可以使用ECMO.疏水性相互作用疏水性相互作用脂质体是一种脂质体.微粒微粒 (Micelles) 是一种微粒.普罗波福尔 (Propofol) 是一种

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