来自患者的致病性微生物沉积增加了儿科诊所的暴露风险
Wan Wang1, Zongyao Qiu2, Hui Li1
1Department of Immunology and Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China; Key Laboratory of Tropical Diseases Control (Sun Yat-sen University), Ministry of Education, Guangzhou 510080, China.
The Science of the total environment
|March 15, 2024
概括
儿科患者是门诊环境中危险细菌的主要来源,通过手接触传播它们. 加强手部卫生和消毒是预防儿童患医疗相关感染的关键.
科学领域:
- 微生物学 微生物学
- 公共卫生 公共卫生
- 传染病流行病学 传染病流行病学
背景情况:
- 医疗相关感染 (HAI) 对门诊环境中的儿科患者构成重大威胁.
- 了解机会性细菌病原体 (OBPs) 的来源和传播对于预防HAI至关重要.
研究的目的:
- 在儿科门诊机构中识别OBP的来源和传播途径.
- 评估与核心OBP相关的公共卫生风险.
- 为了描述OBPs的抗生素耐药性概况.
主要方法:
- 从儿科门诊区域收集了310个样本.
- 使用qPCR和CFU计数量化细菌.
- 进行了16S rRNA基因测序和全基因组测序,用于传播和抗生素耐药性分析.
主要成果:
- 儿科患者的手是多人接触区域内OBP的主要来源.
- 五个核心的OBPs (Staphylococcus epidermidis,Acinetobacter baumannii,Pseudomonas aeruginosa,Streptococcus mitis,Streptococcus oralis) 被追溯到儿科患者. 这一研究的结果是:
- 抗生素耐药性基因在儿科患者的S. epidermidis中更为普遍;多药耐药的A. baumannii在儿童-父母对中被发现.
结论:
- 儿科患者是OBP的重要储备,构成高公共卫生风险.
- 有效的HAI控制需要改善儿科患者的手部卫生和频繁消毒高接触区域.
- 有针对性的干预措施可以减少OBP的传播,并减轻儿科门诊机构的HAI风险.
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