一种来自自然的,异构的,有利于愈合的生物粘合贴片,用于高性能密封湿组织
Shilin Liu1, Yangfan Xiang1, Zekun Liu1
1Chongqing Key Laboratory of Oral Disease and Biomedical Sciences, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Stomatological Hospital of Chongqing Medical University, Chongqing, 401174, P. R. China.
Advanced materials (Deerfield Beach, Fla.)
|March 15, 2024
概括
一个新的生物粘合贴来源于的分泌物强烈粘附于湿组织,提供快速,无的伤口关闭. 这种再生补丁在具有挑战性的环境中显示出对各种手术应用的前景.
科学领域:
- 生物材料科学 生物材料科学
- 再生医学是一种再生医学.
- 手术创新 在外科创新.
背景情况:
- 传统的伤口关闭方法,如和紧固件,面临着局限性,特别是在湿或暴露于液体的组织上.
- 现有的组织粘合剂在具有挑战性的生理条件下经常失败,包括不同的pH值,机械应力和液体存在.
- 需要先进的伤口关闭解决方案,在多样化和极端的体内环境中有效.
研究的目的:
- 开发一种新的,自然衍生的多层异质生物粘合贴,用于有效的湿组织粘附和伤口愈合.
- 为了创建一个由压力触发的,从Andrias davidianus (SSAD) 的皮肤分泌物中获得的亲疗生物粘合剂.
主要方法:
- 开发一种多层异质生物粘合贴,使用来自SSAD的水友性/疏水性成分.
- 在体内测试SSAD-Patch在各种严重伤害模型上,包括胃肠道穿孔,血管切口和肺部撕裂.
- 在各种条件下评估粘合强度和密封能力,包括高压和不同pH值.
主要成果:
- 在所有测试的极端伤害场景中,SSAD-Patch表现出快速 (在10秒内) 和强大的粘附于湿组织.
- 在密封和治愈各种缺陷的成功应用,包括胃和肠道穿孔,胎儿膜缺陷,动脉切口和肺叶伤.
- 贴片在各种压力和模拟生理条件下保持了功能.
结论:
- 开发的SSAD-Patch代表了一种有前途的自粘性再生材料,用于无伤口密封和愈合.
- 它对不同pH值和压力的适应性表明它在具有挑战性的外科环境中具有广泛的潜在应用.
- 这种来自自然的生物粘合剂比传统的伤口关闭技术有了显著的进步.
相关概念视频
01:42The Extracellular Matrix
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.Composition of the Extracellular MatrixThe extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse molecules.
01:29The Extracellular Matrix
Overview
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
01:11Fibril-associated Collagen
Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
01:25Fibronectins Connect Cells with ECM
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Both proteoglycans and collagen are attached to fibronectin proteins, which, in turn, are attached to integrin proteins. These integrin proteins interact with transmembrane...
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00:55Laminins are the Adhesive Proteins of Basal Lamina
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In humans, the five forms of alpha chains are LAMA 1, LAMA 2, LAMA 3, LAMA 4, and LAMA 5. The four forms of beta chains are LAMB 1, LAMB 2, LAMB 3, and LAMB 4. The three forms of gamma...
In humans, the five forms of alpha chains are LAMA 1, LAMA 2, LAMA 3, LAMA 4, and LAMA 5. The four forms of beta chains are LAMB 1, LAMB 2, LAMB 3, and LAMB 4. The three forms of gamma...
01:20Cell Adhesion Molecules - Types and Functions
Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily involved in a...
CAM Families
The Integrin family of proteins is primarily involved in a...