免疫接种后的不良事件:前性队列研究,评估澳大利亚儿童提交专业免疫诊所的不良事件
Hannah Stubbs1, Pamela Palasanthiran2, Archana Koirala3
1Faculty of Medicine, University of New South Wales, Sydney, Australia.
Vaccine
|March 15, 2024
概括
对于免疫接种后有不良事件史的儿童,再接种疫苗通常是安全的. 大多数在免疫接种后出现过先前不良事件的儿童没有复发,这表明未来接种疫苗的安全性.
科学领域:
- 儿科 儿科 儿科
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- 免疫接种后的不良事件 (AEFI) 可以阻止接种疫苗.
- 澳大利亚对儿童AEFI复发的数据有限.
- 了解复发风险对于临床决策至关重要.
研究的目的:
- 评估在有AEFI病史的儿童免疫接种后不良事件的复发率.
- 评估是否有AEFI家族史会增加复发的风险.
- 为了为以前有AEFI的儿童提供疫苗接种策略的信息.
主要方法:
- 在2023年3月至8月期间进行的前性队列研究.
- 招募的儿童年龄小于16岁,有AEFI (个人或家庭病史).
- 通过疫苗接种后3天和8天的调查收集了AEFI结果.
主要成果:
- 87.8%的儿童接种了更多的疫苗.
- 在完成随访的患者中,50.0%的人报告了AEFI.
- 23.3%的患者曾经有过AEFI的复发;严重AEFI的复发率为16.7%,而在那些曾经有过严重AEFI的人群中,这一比例为16.7%.
- 神经疾病是疫苗接种后发作的一个危险因素.
- 家庭病史与疫苗接种后的AEFI没有相关性.
结论:
- 对大多数有AEFI个人或家族病史的儿童来说,再接种疫苗是安全的.
- 该研究提供了有关AEFI复发的宝贵澳大利亚数据.
- 这些发现支持在危险儿科人群中继续进行疫苗接种工作.
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