患有支气管肺功能障碍 (BPD) 的极度早产婴儿的神经发育结果 - 一项回顾性队列研究
Khoa L Nguyen1, Dominic A Fitzgerald2, Annabel Webb3
1The Children's Hospital at Westmead, Locked Bag 4001 Westmead, NSW, 2145, Australia.
Paediatric respiratory reviews
|March 15, 2024
概括
大多数29周前出生的患有支气管肺功能障碍症 (BPD) 的早产婴儿在神经发育方面比预期的要好. 那些需要呼吸辅助的人患病率更高.
科学领域:
- 新生儿医学 新生儿医学
- 发育儿科 发育儿科
- 呼吸系统医学 呼吸系统医学
背景情况:
- 支气管肺功能障碍症 (BPD) 是早产婴儿的常见并发症.
- 极度早产婴儿患有BPD的神经发育结果是一个重大问题.
- 了解BPD严重程度对长期神经发育的影响至关重要.
研究的目的:
- 为了研究早产婴儿在怀孕29周之前出生的神经发育结果.
- 为了比较患有和没有支气管肺功能障碍 (BPD) 的婴儿之间的结果.
- 评估呼吸支需求对BPD婴儿神经发育障碍的影响.
主要方法:
- 在澳大利亚新南威尔士州和ACT州2007-2018年间出生的早产婴儿 (妊娠29周以下) 的队列研究.
- 不包括在月经后36周之前死亡的婴儿或具有重大先天性异常的婴儿.
- 在18-42个月时进行神经发育评估,使用贝利婴儿发育尺度进行年龄校正,第三版.
主要成果:
- 对1436名非BPD和1189名BPD婴儿进行了跟踪.
- 中度神经发育障碍 (NDI) 的发生率为:5.7% (非BPD),11% (BPD1),15% (BPD2),15% (BPD3).
- 严重的NDI率为1.7% (非BPD),3.4% (BPD1),7.3% (BPD2),35% (BPD3) 的患者. 患有BPD2或BPD3的婴儿的中度至重度NDI的几率明显更高.
结论:
- 大多数患有BPD的婴儿在没有呼吸辅助的情况下出院.
- 患有BPD的婴儿需要家庭氧气或呼吸系统支持,他们患中度至重度神经发育障碍的风险增加.
- 早期儿童的神经认知结果受到BPD的严重程度和呼吸支持需求的影响.
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