来自DNA聚合酶α-原酶的催化结构的原料合成的机械模型

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Updated: Jun 30, 2025

DNA Sequence Recognition by DNA Primase Using High-Throughput Primase Profiling
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DNA Sequence Recognition by DNA Primase Using High-Throughput Primase Profiling

Published on: October 8, 2019

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Elwood A Mullins1,2, Lauren E Salay2,3,4, Clarissa L Durie5,6,7

  • 1Department of Biological Sciences, Vanderbilt University, Nashville, TN, USA.

Nature structural & molecular biology
|March 16, 2024
PubMed
概括

聚合酶α-原酶 (polα-原酶) 为基因组稳定性创造RNA-DNA原料. 新的冷EM结构揭示了聚α-原酶如何调节原料合成和终止,为复制启动提供了一个全面的模型.

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