计算不同治疗途径的偏好估计的新方法:在瘤学中的应用
Kathleen Beusterien1, Oliver Will2, Emuella Flood3
1Real World Evidence, Oracle, Kansas City, MO, USA. kathleen.beusterien@oracle.com.
The patient
|March 16, 2024
概括
患者优先考虑避免严重不良事件,并更喜欢灵活的癌症治疗途径. 这项研究开发了一种新的方法来评估患者在复杂的治疗序列中的偏好.
科学领域:
- 在瘤学瘤学.
- 医疗保健服务研究 医疗服务研究
- 决策科学 决策科学 决策科学
背景情况:
- 癌症患者经常接受连续治疗,并产生不同的副作用.
- 治疗途径可以固定或灵活,允许根据结果进行调整.
- 需要一种方法来估计患者对整个治疗序列的偏好.
研究的目的:
- 开发一种新的方法来估计患者在复杂,连续的癌症治疗途径中的偏好.
- 评估患者对早期乳腺癌治疗途径关键属性的偏好.
主要方法:
- 在早期乳腺癌患者中进行了一项在线离散选择实验.
- 层次贝叶斯模型计算了属性级别偏好权重.
- 通过对疗效,疗程灵活性,持续时间,施用和不良事件进行时间调整权重的总和,估计了途径偏好.
主要成果:
- 严重不良事件风险是治疗途径偏好的最重要因素.
- 患者表现出强烈的偏好灵活而不是固定的治疗途径.
- 提高疗效和减少疗程持续时间也对偏好产生了积极的影响.
结论:
- 一种新的方法允许对顺序癌症治疗进行全面的患者偏好评估.
- 这种方法有助于基于患者价值的复杂治疗途径的比较.
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