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在帕金森病和后病毒性嗅觉功能障碍中,后皮质皮质的差异连接性:fMRI研究
Charalampos Georgiopoulos1,2, Martha Antonia Buechner3, Bjoern Falkenburger4
1Diagnostic Radiology, Department of Clinical Sciences, Medical Faculty, Lund University, Lund, Sweden. Charalampos.Georgiopoulos@med.lu.se.
Scientific reports
|March 16, 2024
概括
与健康个体相比,帕金森病 (PD) 患者在后皮质皮质 (PPC) 中显示出大脑连接的改变. 这种嗅觉功能障碍凸显了PD受影响的高阶处理网络的差异.
科学领域:
- 神经科学是一个神经科学.
- 嗅觉系统研究 嗅觉系统研究
- 大脑连接研究研究大脑连接研究
背景情况:
- 嗅觉功能障碍是后病毒 (PV) 感染和异常性帕金森病 (PD) 的共同症状.
- 后状皮质 (PPC) 是一个关键的嗅觉区域,在处理气味方面发挥着至关重要的作用.
- 了解PPC连接差异可以阐明疾病机制.
研究的目的:
- 在患有病毒后感染 (PV) 和帕金森病 (PD) 的患者中比较后皮质皮质 (PPC) 连接性.
- 在健康对照,PV和PD组中识别与PPC相关的独特大脑网络.
- 研究PD对与嗅觉系统相关的更高阶处理网络的影响.
主要方法:
- 基于任务的嗅觉功能磁共振成像 (fMRI) 使用桃子和鱼的气味.
- 使用协同激活模式 (CAP) 工具箱对fMRI数据进行动态PPC连接性评估的分析.
- 对15名健康对照,15名PV患者和14名PD患者的大脑网络活动的比较.
主要成果:
- 确定了与PPC相互作用的两个不同的大脑网络.
- 一个涉及情绪和注意区域的网络 (前带膜,中前回旋) 与对照组相比,在PD患者中活跃度明显低.
- 在这个网络中,在PV患者和其他群体之间没有观察到任何显著的差异.
- 第二个网络显示了嗅觉和额头区域之间的分离,在后期刺激期间活动增加,表明习惯.
- 嗅觉习惯似乎独立于疾病状态.
结论:
- 后皮质皮质 (PPC) 与更高阶的处理区域相互作用,而这种网络在帕金森病 (PD) 中发生显著变化.
- 研究结果表明,嗅觉习惯机制在健康人群,PV和PD患者中得到保留.
- 这项研究提供了对PD嗅觉功能障碍的神经基础的洞察.
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