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Updated: Jun 30, 2025

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早期检测使用Ga-FAPI-04成像对人环素诱导的心脏毒性

Zhuxin Wei¹, Hongchuang Xu², Bixi Chen³

¹Department of MRI, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beilishi Rd 167, Xicheng District, Beijing, 100037, China.

European journal of nuclear medicine and molecular imaging

|March 16, 2024

概括

用Ga标记的纤维细胞激活蛋白 (FAP) 抑制剂PET/CT有效地检测了在环素诱导的心脏毒性的早期纤维化. 这种成像可以指导抗纤维素治疗,保持心脏功能并减少心肌损伤.

科学领域:

心脏病学心脏病学
在瘤学瘤学.
放射学放射学是一门学科.
核医学就是核医学.

背景情况:

人环素诱导的心脏毒性 (AIC) 是癌症治疗中的一个重大临床挑战,主要表现为心肌纤维化.
早期识别和干预对于管理AIC和预防不可逆转的心脏损伤至关重要.

研究的目的:

评估使用Ga标记纤维细胞激活蛋白 (FAP) 抑制剂 (Ga-FAPI) PET/CT用于早期检测AIC中的纤维化过程的可行性.
评估[⁶⁸Ga]Ga-FAPI PET/CT在指导AIC抗纤维治疗中的潜力.

主要方法:

通过使用多克索鲁比 (DOX) 给药,建立了一个AIC大鼠模型.
在DOX诱导后的不同时间点进行了Ga-FAPI PET/CT.
评估了组织病理学分析 (H&E,FAP IHC,Sirius红色,马森三色) 和生化标志物.
用心声图来评估心脏功能,并使用 ACE 抑制剂 (伊纳拉普利尔) 评估治疗疗效.

主要成果:

在AIC大鼠中,与3周和6周的对照组相比,心脏中的Ga-FAPI吸收显著增加.
从可检测的不可逆转纤维化之前的第3周开始观察到FAP表达的增加.
埃纳拉普利尔治疗导致Ga-FAPI积累减少,心脏功能 (LVEF) 保持,心肌纤维化减弱.
以Ga-FAPI PET/CT为指导的早期治疗显示出缓解AIC的有希望的结果.

结论:

[⁶⁸Ga]Ga-FAPI PET/CT是一种可行的工具,用于在AIC中早期检测活跃心肌纤维化.
这种成像模式可以有效地评估抗纤维菌治疗干预措施的疗效.
以Ga-FAPI PET/CT为指导的早期治疗干预有可能减少心肌损伤并改善AIC患者的心脏功能.

关键词:

抑制了ACE的抑制.人环素诱导的心脏毒性纤维细胞激活蛋白质的激活蛋白质聚乙烯/聚乙烯/聚乙烯 [68 Ga]Ga-FAPI 的时间

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