在子中对Omicron BA.4.6,XBB和BQ.1.1亚变体的表征
Peter J Halfmann1, Kiyoko Iwatsuki-Horimoto2, Makoto Kuroda1
1Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, 53711, USA.
Communications biology
|March 16, 2024
概括
新的Omicron亚型如BQ.1.1和XBB显示肺部复制增加,并可能是致命的,突出显示需要持续监测不断演变的SARS-CoV-2变种.
科学领域:
- 病毒学 病毒学
- 传染性疾病 传染性疾病
- 分子生物学分子生物学
背景情况:
- 欧米克朗浪潮迅速取代了SARS-CoV-2变种,包括BA.2,BA.4和BA.5,由具有尖端蛋白突变的新菌株取代.
- 新兴的亚变种如BA.4.6,BQ.1.1,XBB已经显示出不同的全球流行率.
研究的目的:
- 评估BA.4.6,BQ.1.1和XBB临床分离物的比较复制能力和致病性.
- 评估这些Omicron亚变体在叙利亚仓鼠模型中的影响.
主要方法:
- 雄性叙利亚仓鼠感染BA.4.6,BQ.1.1和XBB临床分离物.
- 评估受感染仓鼠的体重变化,肺组织复制和致死率.
- 竞争测定先前感染了Omicron BA.2.的雌性仓鼠.
主要成果:
- 在被测试的Omicron亚变体感染的仓鼠群体中没有观察到显著的体重变化差异.
- 与BA.4.6和BA.5.5相比,BQ.1.1和XBB在肺组织中表现出更高的复制率.
- BQ.1.1 在男性和女性转基因人类ACE2仓鼠中都被证明是致命的.
- 在之前患有BA.2感染的雌性仓鼠的鼻中,XBB表现出比BQ.1.1更好的复制性.
结论:
- BQ.1.1和XBB亚变体表现出增强的致病性和复制性,特别是在肺组织中.
- XBB 血统继续发展,在特定的主机环境中显示出竞争优势.
- 密切监测像XBB这样的新出现的Omicron亚型变种是至关重要的,因为它们有可能增加传播能力和毒性.
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