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Updated: Jun 30, 2025

A Protocol for Computer-Based Protein Structure and Function Prediction
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VirtuousPocketome:一种用于选蛋白质-连接体复合体的计算工具,以识别类似的结合点

Lorenzo Pallante1, Marco Cannariato1, Lampros Androutsos2

  • 1Department of Mechanical and Aerospace Engineering, Politecnico di Torino, PolitoBIOMedLab, 10129, Torino, Italy.

Scientific reports
|March 16, 2024
PubMed
概括

一个新的计算管道,VirtuousPocketome,在庞大的数据库中识别了类似的蛋白质结合口袋. 该工具有助于预测蛋白质-连接体相互作用,并通过分析蛋白质结构来发现新的治疗点.

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Conserved Binding Sites01:49

Conserved Binding Sites

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Ligand Binding Sites

Proteins are dynamic macromolecules that carry out a wide variety of essential processes; however, the activities of most proteins depend on their interactions with other molecules or ions, known as ligands.
Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...
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Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
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The Equilibrium Binding Constant and Binding Strength

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