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Updated: Jun 30, 2025

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection
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与空间解析的转录学数据进行基准测试的空间聚类方法

Zhiyuan Yuan1,2, Fangyuan Zhao3,4, Senlin Lin3,4

  • 1Center for Medical Research and Innovation, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Fudan University, Shanghai, China. zhiyuan@fudan.edu.cn.

Nature methods
|March 16, 2024
PubMed
概括

本研究对使用空间解析转录组学 (SRT) 数据进行空间聚类的13种计算方法进行了基准测试. 它揭示了互补的方法性能,但强调了处理复杂的空间领域和大规模任务的局限性.

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相关概念视频

RNA-seq03:21

RNA-seq

RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while...
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