在高血糖症中,适当的血糖管理可以保护生殖线,但不能保护子宫环境
Allan Zhao1, Hong Jiang1, Arturo Reyes Palomares2
1Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
EMBO reports
|March 16, 2024
概括
母亲糖尿病通过表观遗传影响后代的健康. 优化的1型糖尿病 (T1D) 模型显示,受控的血糖水平保持了卵细胞的健康,但子宫环境会影响胎儿的发育.
科学领域:
- 生殖生物学 生殖生物学
- 内分泌学 在内分泌学.
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 父母的疾病可以在表观遗传上影响后代的健康.
- 母亲糖尿病与卵细胞转录组变化和后代代谢功能障碍有关.
- 现有的1型糖尿病 (T1D) 鼠标模型存在因高血糖症而导致的混因素,限制了临床相关性.
研究的目的:
- 在一个优化的T1D小鼠模型中,研究受控的孕产妇血糖水平对卵细胞和子宫内发育的影响.
- 评估在体外成熟过程中轻微升高的葡萄糖对人类卵细胞转录组的影响.
- 为了区分生殖系与子宫环境对管理糖尿病的发育编程的贡献.
主要方法:
- 针对可控高血糖的T1D小鼠模型的优化.
- 在糖尿病小鼠中分析卵细胞转录组和染色质可访问性.
- 在体外成熟的人类卵子细胞与轻微增加的葡萄糖水平.
- 在T1D小鼠模型中评估胎儿生长和胎盘功能.
主要成果:
- 控制血糖的糖尿病小鼠保持了卵细胞转录组和染色质可访问性.
- 人类卵细胞在体外成熟时,葡萄糖水平略有增加,但仍保留了他们的转录组.
- 尽管控制了母体血糖,胎儿生长和胎盘功能在T1D小鼠模型中受损.
结论:
- 适当管理的孕产妇糖尿病可以保持卵细胞质量和转录组.
- 子宫环境,而不是生殖系,似乎是影响子宫内发育的主要因素.
- 研究结果表明,针对子宫环境的潜在干预措施可以改善糖尿病管理的怀孕结果.
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