在皮层网络中,激发性-抑制性调整等效的本地来源
Adrian J Duszkiewicz1,2,3, Pierre Orhan4,5, Sofia Skromne Carrasco4
1Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada. aduszkie@ed.ac.uk.
Nature neuroscience
|March 16, 2024
概括
在大脑中抑制神经元调节.
科学领域:
- 神经科学是一个神经科学.
- 计算神经科学是一种神经科学.
- 系统神经科学 系统神经科学
背景情况:
- 皮层电路功能依赖于神经元激发和抑制之间的平衡.
- 抑制性神经元的调原理比激发性神经元的调原理要少.
- 后 (PoSub) 中的头向 (HD) 细胞为研究皮层表示提供了一个模型系统.
研究的目的:
- 为了研究小鼠后细胞 (PoSub) 中快速激增 (FS) 抑制神经元的调特性.
- 为了确定FS细胞和激发性HD细胞在同一网络中的调整之间的关系.
- 阐明在PoSub.中FS细胞调整背后的机制.
主要方法:
- 在老鼠PoSub中的神经元活动的体内群体记录.
- 在PoSub.Sub上游的thalamic输入的光遗传学操纵.
- 对神经元调曲线的福利埃转换分析.
- 本地网络动态的计算建模.
主要成果:
- PoSub FS细胞表现出广泛的,通常是辐射对称的调节,与微调刺激神经元不同.
- 里埃分解揭示了FS和HD细胞群之间的调特征的等价性.
- 有证据表明,FS单元调整源于本地网络交互,而不仅仅来自上游输入.
结论:
- 在PoSub中抑制FS细胞的调整本质上是由局部网络属性塑造的.
- 激发性和抑制性群体之间的同等调整可能是局部皮质网络的一般原则.
- 这些发现推动了我们对抑制如何促进神经编码和皮质电路功能的理解.
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