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在年轻和中年人群中,sarcopenia和与代谢功能障碍相关的脂肪肝疾病之间的关系
Ziyan Feng1, Fanrong Zhao2, Ziyao Wang1
1Department of Medical Ultrasound and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, No. 37, Guoxue Lane, Wuhou District, Chengdu, Sichuan Province, China.
与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 与成人肉类症的发病率较高有关. 建议对患有MAFLD的患者进行早期查和改变生活方式.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 代谢障碍 代谢障碍 代谢障碍
- 老年病的医生 老年病的医生
背景情况:
- 与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 越来越多地被认为是一种全身性疾病.
- 肝外表现,如肉,与MAFLD有关,但年轻人和中年人的关系尚不清楚.
研究的目的:
- 在年轻和中年成年人中调查MAFLD和肉症之间的关联.
- 探索这种关系中的潜在调解因素和子组差异.
主要方法:
- 分析了2017-2018年NHANES2214名参与者的实验室,DXA和超声波短暂弹性学数据.
- 根据脂肪肝加上超重/肥胖,糖尿病或代谢失调诊断的MAFLD;根据BMI调整的尾肌肉质量定义的肉类;根据BMI调整的脂肪肝.
- 采用了多变量逻辑回归,受限立方线 (RCS) 模型和调解分析.
主要成果:
- MAFLD的患病率为47.85%,而sarcopenia的患病率为8.05%.
- 在患有MAFLD (12.75%) 的人群中,与没有MAFLD的人群相比 (3.73%),萨科佩尼亚的患病率显著增加.
- MAFLD显示与肉症 (OR=2.87) 有显著的积极关联,线性相关,并由C-反应蛋白和HDL胆固醇介导.
结论:
- MAFLD的患病率和严重程度与年轻和中年成人中 Sarcopenia 有显著的关联.
- 临床医生应考虑对伴随性疾病进行查,并促进MAFLD患者的生活方式的改变.
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