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Updated: May 9, 2026

A GPC3-targeting Bispecific Antibody, GPC3-S-Fab, with Potent Cytotoxicity
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几何抗体工程揭示了对双特异性T细胞激活剂有效性的空间因素

Yu Zhang1,2, Zhe Yang1, Dilizhatai Saimi1

  • 1College of Future Technology, Institute of Molecular Medicine, National Biomedical Imaging Center, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Peking University, Beijing 100871, China.

ACS chemical biology
|March 16, 2024
PubMed
概括

双特异性抗体 (BsAbs) 的空间安排显著影响T细胞参与剂 (TCE) 疗效. 循环TCEs,特别是使用类酶A的TCEs,显示出增强的效能和稳定性,以改善免疫疗法.

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相关概念视频

Antibody Structure01:10

Antibody Structure

Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...