相关实验视频

Updated: Jun 30, 2025

High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents HPHC
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High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents HPHC

Published on: May 10, 2016

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α-Pyrrolidinohexanophenone (α-PHP) 与α-pyrrolidinoisohexanophenone (α-PiHP):在法医常规病例中对血度和行为进行毒理学调查

Isabel Brueckner1, Jessica Welter-Luedeke1, Anna Zangl1

  • 1Department of Forensic Toxicology, Institute of Legal Medicine, Faculty of Medicine, Ludwig-Maximilians-Universität in Munich, Nussbaumstraße 26, Munich 80336, Germany.

Journal of analytical toxicology
|March 16, 2024
PubMed
概括

新的精神活性物质,如α-pyrrolidinohexanophenone (α-PHP) 和α-pyrrolidinoisohexanophenone (α-PiHP) 是普遍存在的. 它们在血中的检测与侵略性行为相关,通常与暴力犯罪有关.

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A Convenient Method for Extraction and Analysis with High-Pressure Liquid Chromatography of Catecholamine Neurotransmitters and Their Metabolites13:35

A Convenient Method for Extraction and Analysis with High-Pressure Liquid Chromatography of Catecholamine Neurotransmitters and Their Metabolites

Published on: March 1, 2018

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Color Spot Test As a Presumptive Tool for the Rapid Detection of Synthetic Cathinones06:06

Color Spot Test As a Presumptive Tool for the Rapid Detection of Synthetic Cathinones

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Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance

The elimination half-life and drug clearance of drugs following nonlinear kinetics can vary with dosage. The Michaelis-Menten parameters and drug concentration influence these factors. As the dose increases, the elimination half-life tends to lengthen, resulting in a reduction in clearance and a disproportionately larger area under the curve. The total clearance can be derived from the Michaelis-Menten equation for drugs following a one-compartment model.
A study on guinea pigs examined the...
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Drug Concentrations: Measurements01:23

Drug Concentrations: Measurements

Drug concentration is the quantity of a drug present in a biological sample. Measuring drug amounts in biological samples allows the clinician to understand how a drug is absorbed, distributed, metabolized, and excreted. Samples can be obtained through invasive or non-invasive methods. Invasive techniques involve surgical or parenteral interventions to gather blood, cerebrospinal fluid, or tissue biopsy. Conversely, non-invasive approaches provide samples like urine, feces, and saliva.
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