持续的COVID-19 parosmia和嗅觉训练后的嗅觉损失:随机临床试验比较中心和外周作用治疗药物
Elena Cantone1, Luca D'Ascanio2, Pietro De Luca3
1Department of Otolaryngology, Federico II University of Naples, Naples, Italy.
概括
在COVID-19患者中,超微克朗化棕甲基乙醇胺和氨酸与嗅觉训练 (OT),有或没有阿尔法-酸,显著改善了嗅觉功能和. 单独或与阿尔法脂酸一起的OT显示出极少的益处.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
背景情况:
- 持续的嗅觉功能障碍 (pOD) 和帕洛斯米亚是COVID-19的常见后果.
- 目前对耐火性帕洛斯米亚的治疗方法有限,需要对新的治疗策略进行研究.
研究的目的:
- 评估四种不同治疗方案的疗效,用于慢性COVID-19嗅觉障碍患者的帕洛斯米亚.
- 为了比较超微缩棕甲基乙醇胺和黄素 (umPEALUT) 加上嗅觉训练 (OT),α-脂酸 (ALA) 加上OT,umPEALUT,ALA和OT的组合,以及单独的OT的结果.
主要方法:
- 八十五名患有pOD和治疗不耐药的帕洛斯米亚的患者被随机分为四组.
- 干预包括umPEALUT + OT,ALA + OT,umPEALUT + ALA + OT,以及单独使用OT (对照组).
- 嗅觉功能在基线和6个月时使用嗅探棒测试 (TDI分数) 和质问卷进行了评估.
主要成果:
- 在umPEALUT和组合组中,TDI得分显著改善 (p < 0.01).
- 在组合组 (96%),其次是对照组 (65%),umPEALUT (53%) 和ALA (29%) 组 (p < 0.001) 中,帕洛斯米亚解决率最高.
- 所有治疗方案都被很好地容忍,没有报告任何显著的不良事件.
结论:
- 有或没有ALA的umPEALUT和OT有效地改善了慢性COVID-19嗅觉障碍患者的嗅觉功能,并减少了帕洛斯米亚.
- 单独或与ALA结合的嗅觉训练对帕洛斯米亚的益处有限.
- 组合疗法 (umPEALUT + ALA + OT) 产生了最高的帕洛斯米亚解决率.
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