分子机制和植物细胞外囊泡的治疗应用
Fatemeh Azizi1, Salva Kazemipour-Khabbazi2, Stefania Raimondo3
1Department of Medical Biotechnology, School of Science and Novel Technologies in Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Molecular biology reports
|March 16, 2024
概括
植物细胞外囊泡 (EVs) 由于其生物分子和安全性,对各种人类疾病具有治疗潜力. 研究正在通过改进的隔离和分析方法来推进它们的临床翻译.
科学领域:
- 生物技术是生物技术.
- 纳米医学是一种纳米医学.
- 植物科学 植物科学
背景情况:
- 来自动物来源的小细胞外囊泡 (sEV) 是已确立的无细胞疗法.
- 由于可扩展的生产和丰富的生物分子载荷,来自植物的EV (或纳米微粒) 正在成为强大的治疗工具.
- 植物电动汽车调解王国间的通信,并在各种疾病中表现出治疗潜力.
研究的目的:
- 审查植物电气体的生理作用.
- 探索植物EV在人类疾病中的治疗作用背后的分子和细胞机制.
- 详细介绍植物EV隔离和临床转化分析的方法方面.
主要方法:
- 文献综述侧重于植物EV生理学,治疗机制和隔离技术.
- 对植物EV应用在癌症,炎症,传染病和组织再生方面的现有研究进行分析.
- 讨论挑战,包括缺乏通用标记物和对转基因植物来源的安全担忧.
主要成果:
- 植物EV含有蛋白质,调节性RNA和具有治疗潜力的二次代谢物.
- 研究表明植物EV在治疗癌症,炎症,传染病和促进组织再生方面的应用,没有观察到有毒性.
- 对于临床使用的隔离,表征和安全性评估的标准化仍然存在重大挑战.
结论:
- 植物电动汽车代表了一个有前途,安全和可扩展的治疗平台.
- 对分子机制和标准化方法的进一步研究对于临床翻译至关重要.
- 解决与转基因植物来源有关的安全问题对于广泛采用至关重要.
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