严重喘患者的疾病负担和治疗现实中的变化
Hiroyuki Nagase1, Hayato Oka2, Hitomi Uchimura2
1Division of Respiratory Medicine and Allergology, Department of Medicine, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo, 173-8605, Japan.
Respiratory investigation
|March 16, 2024
概括
严重喘患者的疾病控制和治疗转移有所改善,随着时间的推移,喘恶化较少. 然而,对于管理严重喘恶化而言,仍有持续的未满足的需求.
科学领域:
- 肺部病理学 肺部病理学
- 流行病学 流行病学
- 药物治疗 药物治疗
背景情况:
- 生物药物可用于严重的喘,但长期控制变化尚不清楚.
- 这项研究研究了严重喘患者的疾病负担和治疗演变.
研究的目的:
- 分析严重喘患者中喘恶化的趋势和治疗模式.
- 为了评估疾病负担和重症喘中药物使用的变化,在五年内.
主要方法:
- 对日本医疗保险数据库 (2015-2019) 的回顾性分析.
- 包括16岁以上的患者,持续吸入性皮质类固醇 (ICS) 治疗喘.
- 根据高剂量ICS,控制药物,口服皮质类固醇持续时间或生物使用来定义严重的喘.
主要成果:
- 在2015年至2019年期间,严重喘患者的比例从15.3%增加到19.0%.
- 严重喘患者经历两次或多次恶化的情况有所减少 (24.4%至21.5%).
- 短效β-激动剂和口服皮质类固醇的处方减少,而长效肌抗体和生物药物的处方增加.
结论:
- 严重喘患者在疾病负担和治疗策略方面经历了改善.
- 尽管取得了进展,但仍然有大量未满足的医疗需求,以管理严重的喘恶化.
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