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Updated: Jun 30, 2025

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由低氧状态诱导的HIF-1α调节了慢性免疫血栓塞缩症中Treg/Th17轴的两极化

Hao Gu1, Zhifa Wang2, Xingjuan Xie3

  • 1Hematologic Disease Laboratory, Beijing Key Laboratory of Pediatric Hematology Oncology, National Key Discipline of Pediatrics (Capital Medical University), Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, China 100045; Department of Immunology, Ministry of Education Key Laboratory of Major Diseases in Children, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, China 100045.

International immunopharmacology
|March 16, 2024
PubMed
概括

缺氧诱导因子-1α (HIF-1α) 通过破坏Treg/Th17平衡,影响免疫血小板缺血 (ITP),从而导致疾病慢性化. 这项研究揭示了HIF-1α.

关键词:
低氧诱导因子-1α (HIF-1α)在ITP中,ITP是ITP.儿科 儿科 儿科在Treg/Th17比率上.

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