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基于TCGA数据库的甲状腺癌中淋巴结转移相关的LncRNAs

Ruijing Liu¹, Wen Liu¹, Jingli Xue¹

¹The Postgraduate Training Base of Jinzhou Medical University (The 960th Hospital of PLA), Jinan 250031, China; Department of Pathology, The 960th Hospital of PLA, Jinan 250031, China.

Pathology, research and practice

|March 16, 2024

概括

十个长非编码RNAs (lncRNAs) 与甲状腺癌转移有关. 特定的lncRNAs如AP002358.1和LRRC52-AS1可能表明预后不佳,并作为诊断标记.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
基因组学就是基因组学.

背景情况:

长非编码RNAs (lncRNAs) 涉及癌症的发展,特别是转移.
识别与转移相关的lncRNA对于了解甲状腺癌进展和患者结果至关重要.

研究的目的:

在甲状腺癌中识别与淋巴结转移相关的长非编码RNA (lncRNAs).
探索这些转移相关的 lncRNAs 对患者预后和治疗指导的临床意义.

主要方法:

利用了来自癌症基因组图谱 (TCGA) 的RNA表达和临床数据以及来自ULCAN数据库的生存数据.
采用R语言和SPSS软件进行lncRNA表达和甲状腺癌淋巴结转移之间的相关性分析.
查了与淋巴结转移显著相关的 lncRNAs.

主要成果:

在淋巴结转移的甲状腺癌中鉴定了10种差异表达的lncRNAs.
四个lncRNAs (LRRC52-AS1,AP002358.1,AC004847.1,AC254633.1) 是过度表达的;六个 (SLC26A4-AS1,LINC01886,LINC01789,AF131216.3,AC062015.1,AL031710.1) 是表达不足的.
增加的AP002358.1和LRRC52-AS1表达与预后不佳相关;AF131216.3和AL031710.1与无进展生存率相关.

结论:

这些已识别的lncRNAs在甲状腺癌的发展和进展中起着重要作用.
像AP002358.1和LRRC52-AS1这样的lncRNA显示出预测转移,临床阶段和患者预后的潜在生物标志物.
对这些lncRNA的进一步研究可能会导致改善甲状腺癌的治疗策略.

关键词:

这是一个LncRNARNA.长的非编码RNA可以编码.淋巴结转移的发生是淋巴结转移.甲状腺癌是什么?甲状腺癌是什么?

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