绝经后女性有正常的BMD,骨折已经恶化了骨微型结构:来自OFELY研究的前性分析
E Sornay-Rendu1, F Duboeuf1, R D Chapurlat1
1INSERM UMR 1033 and Université de Lyon, France.
Bone
|March 16, 2024
概括
绝经后妇女的脆弱性骨折与骨微观架构不良有关,即使骨矿物质密度正常. 这突显了评估骨结构对没有骨质疏松症的女性骨折风险的重要性.
科学领域:
- 骨生物学和骨质疏松症研究
- 老年医学和骨健康
- 医学成像和诊断 医学成像和诊断
背景情况:
- 大多数经历脆弱性骨折的绝经后妇女的骨矿物密度 (BMD) 超过了骨质疏松症值.
- 在这些女性中,有相当多的女性患有正常的区域性骨髓瘤 (aBMD).
研究的目的:
- 为了前性地研究脆弱性骨折和骨微型架构 (MA) 之间的关联.
- 评估MA使用高分辨率外周计算机断层扫描 (HR-pQCT) 在正常aBMD的绝经后妇女.
主要方法:
- 来自OFELY研究的586名绝经后妇女的前性随访.
- 测量骨MA (HR-pQCT) 和aBMD (DXA) 在距离半径和骨.
- 分析了15年中位数发生的脆弱性骨折.
主要成果:
- 患有脆弱性骨折的女性显示体积密度,皮质面积 (Ct. Ar),皮质厚度 (Ct. Th),度 (K) 和半径估计故障负载 (FL) 的受损.
- 降低体积密度,Ct. Ar,Ct. Th,K和FL显著与所有脆弱性骨折 (HR 1.44-1.56) 和主要骨质疏松性骨折 (HR 1.66-2.57) 的风险增加有关.
- 在小腿骨上观察到较小的骨MA损伤.
结论:
- 绝经后妇女的脆弱性骨折与骨微型结构的恶化有关,独立于正常的 BMD.
- 骨微型架构评估可以改善正常或骨折性骨质疏松症的女性骨折风险预测.
更多相关视频
07:12Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
Published on: September 28, 2017
8.2K
09:02Cortical Bone Assessment Using Ultrasonic Guided Waves: A Reproducibility Study in a Healthy Population
Published on: January 31, 2025
455
相关概念视频
01:29Bone Disorders
3.5K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.5K
01:40Bone Remodeling
38.3K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.3K
01:31Osteoclasts in Bone Remodeling
2.9K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
2.9K
01:28Menopause
158
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
158