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Updated: Jun 30, 2025

Co-Culture of Murine Small Intestine Epithelial Organoids with Innate Lymphoid Cells
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PD-1 调节着 ILC3 驱动的肠道免疫力和恒常性

Nicolas Jacquelot1, Le Xiong2, Wang H J Cao3

  • 1Department of Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary, Calgary, Canada; Department of Microbiology, Immunology and Infectious Diseases, Cumming School of Medicine, University of Calgary, Calgary, Canada; Arnie Charbonneau Cancer Research Institute, Calgary, Canada.

Mucosal immunology
|March 16, 2024
PubMed
概括

在肠道免疫细胞 (ILC3) 上的编程细胞死亡1 (PD-1) 增强了对肠道健康至关重要的INTERLEUKIN-22 (IL-22) 生产. PD-1信号传递对于保持肠道屏障完整性和恒常性至关重要.

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