对PPI加上Alginate与单独使用PPI用于治疗GERD的元分析
1Xiamen University, Xiamen, Fujian, China; Zhongshan Hospital Xiamen University, Xiamen, Fujian, China.
Journal of voice : official journal of the Voice Foundation
|March 16, 2024
概括
在胃食道逆流性疾病 (GERD) 治疗中,将阿尔金酸盐添加到质子抑制剂 (PPI) 中,与单独使用PPI相比,症状或安全性没有显著改善. 建议对GERD亚型进行进一步的研究.
科学领域:
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 胃食道逆流性疾病 (GERD) 是一种常见的疾病,其特征是酸性逆流.
- 质子抑制剂 (PPI) 是GERD的主要治疗方法.
- 酸是一种海藻衍生物质,有时作为辅助疗法用于改善GERD症状控制.
研究的目的:
- 系统地评估PPI与阿尔金酸盐结合的临床疗效和安全性,而不是单独使用PPI治疗GERD.
- 为了确定阿尔金酸盐在减少GERD患者的症状和不良事件概况方面是否具有显著的益处.
主要方法:
- 进行了随机对照试验 (RCT) 的系统审查和元分析.
- 在PubMed,Embase和Cochrane图书馆进行了相关研究的搜索.
- 使用Rev Man 5.4软件进行了偏差风险评估和统计分析.
主要成果:
- 这项分析包括了四项涉及608名患者的RCT.
- 在单独使用组合疗法和PPI之间,在减轻胃灼热或吐得分方面没有观察到统计学上显著的差异.
- 没有烧的天数和不良事件的发生率在两组之间也没有显著差异.
结论:
- 结合阿尔金酸盐和PPI治疗GERD并没有显示出与单独使用PPI相比,有效性的统计学上显著改善.
- 当与PPI一起使用时,酸似乎不会增加不良事件的发生率.
- 需要进一步进行高质量的研究,可能专注于特定的GERD亚型,以完善治疗策略.
更多相关视频
相关概念视频
Peptic Ulcer Disease IV: Management
91
Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
91
Gastroesophageal Reflux Disease II: Clinical Features and Management
80
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
80
Acid Suppressive Drugs for Peptic Ulcer Disease: Proton Pump Inhibitors
430
Peptic ulcers, often induced by H. pylori infections or NSAID usage, arise from disruptions in the delicate balance of gastric acid production. Peptic ulcers stem from heightened gastric acid levels due to H. pylori infections or NSAID use. The protective mucus layer diminishes in the presence of these factors, allowing gastric acid to erode the stomach lining and form ulcers.
Gastric acid, a potent cocktail of hydrogen and chloride ions, is produced in specialized parietal cells within the...
Gastric acid, a potent cocktail of hydrogen and chloride ions, is produced in specialized parietal cells within the...
430
Drugs for Peptic Ulcer Disease: Prostaglandin Analogs as Mucosal Protective Agents
434
The gastric mucosa produces prostaglandins E2 (PGE2) and prostacyclin (PGI2), crucial in maintaining gastric health. They exert cytoprotective effects, including increasing bicarbonate secretion, releasing protective mucin, reducing gastric acid output, and preventing harmful vasoconstriction. These effects are mediated through various receptors, such as EP1, EP2, EP3, and EP4.
Non-steroidal anti-inflammatory drugs (NSAIDs) can induce peptic ulcers by inhibiting cyclooxygenase, decreasing...
Non-steroidal anti-inflammatory drugs (NSAIDs) can induce peptic ulcers by inhibiting cyclooxygenase, decreasing...
434
Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy
396
Helicobacter pylori, a resilient gram-negative bacterium, can thrive in the stomach's harsh, acidic environment. Infection with H. pylori leads to a cascade of events within the stomach lining. One of the critical disruptions caused by this bacterium is the interference with somatostatin production, a hormone responsible for regulating acid secretion. This interference tips the balance, escalating acid secretion and diminishing bicarbonate levels. This imbalance compromises the defensive...
396
Acid Suppressive Drugs for Peptic Ulcer Disease: Antacids
368
In the complex environment of the gastric lumen, excessive acid secretion can lead to the formation or worsening of ulcers within the delicate mucosal layer. Antacids, such as sodium bicarbonate and calcium carbonate, provide relief by neutralizing this acid, transforming it into harmless salt and water. This neutralization process raises the gastric pH from a highly acidic level of 1 to a more basic 3-4, reducing the acidity within the stomach.
However, this neutralization reaction between...
However, this neutralization reaction between...
368


