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Updated: Jun 30, 2025

Artificial RNA Polymerase II Elongation Complexes for Dissecting Co-transcriptional RNA Processing Events
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关于人类RNA结合酶RTCB被Archease激活的结构和机制见解

Janina Lara Gerber1, Suria Itzel Morales Guzmán1, Lorenz Worf1

  • 1Heidelberg University, Biochemistry Center (BZH), Im Neuenheimer Feld 328, Heidelberg, Germany.

Nature communications
|March 17, 2024
PubMed
概括

这项研究揭示了Archease如何激活人类RTCB酶用于RNA结合. 结构分析表明,Archease促进共价中间体的形成,并防止在这个关键的细胞过程中过早结合RNA.

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