用计算机断层扫描进行肺癌查:加拿大预防性医疗保健工作组的系统审查协议
Jennifer Pillay1, Sholeh Rahman2, Scott Klarenbach3
1Alberta Research Centre for Health Evidence, University of Alberta, 11405 87 Avenue NW, Edmonton, Alberta, T6G 1C9, Canada. jpillay@ualberta.ca.
Systematic reviews
|March 17, 2024
概括
本系统性审查更新了肺癌查的证据,以告知加拿大预防性医疗保健工作组的指导方针. 它检查CT查的益处,危害和患者价值,以改善早期检测和治疗结果.
科学领域:
- 公共卫生 公共卫生
- 预防医学 预防医学
- 在瘤学瘤学.
背景情况:
- 肺癌是加拿大癌症死亡的主要原因之一.
- 通过查及早检测可以提高治疗可治性,降低死亡率.
- 目前的查指南需要根据新证据进行更新.
研究的目的:
- 更新关于计算机断层扫描 (CT) 查肺癌的益处和危害的综述.
- 对选择标准,风险预测模型和结节分类系统的比较有效性进行新的审查.
- 评估患者对肺癌查的价值观和偏好.
主要方法:
- 在多个数据库 (Medline,Embase,Cochrane Central,Scopus,EconLit) 中进行系统的文献搜索.
- 包括随机对照试验,非随机研究和关于患者偏好的定量研究.
- 在适当的情况下使用元分析提取和合成数据,否则则使用描述性合成.
- 使用GRADE进行偏差风险评估和证据确定性评级.
主要成果:
- 自2015年以来发表的新试验和更长的随访报告提供了关于查益处和危害的最新数据.
- 将分析不同选择标准和结节分类系统的比较有效性.
- 患者的价值观和偏好将被系统地审查,以告知利益与危害的平衡.
结论:
- 更新的证据将为加拿大预防性医疗保健工作组对肺癌查的修订建议提供信息.
- 对益处,危害和患者价值的全面理解对于优化查策略至关重要.
- 这些发现将支持肺癌预防计划的基于证据的决策.
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