晚期大脑衰老在帕金森病中与认知障碍相关
Chang-Le Chen1,2, Shao-Ying Cheng3, Leila Montaser-Kouhsari4
1Institute of Medical Device and Imaging, National Taiwan University College of Medicine, Taipei, Taiwan.
NPJ Parkinson's disease
|March 17, 2024
概括
与没有认知障碍 (PD-NCI) 患者相比,患有帕金森病和认知障碍 (PD-CI) 的患者表现出加速的大脑衰老. 在PD-CI中这种先进的大脑衰老与较差的认知功能有关,并可能作为一个关键的生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 放射学 放射学是一门学科.
- 老年学是一门学科.
背景情况:
- 带有认知障碍的帕金森病 (PD-CI) 的进展速度比没有认知障碍的帕金森病 (PD-NCI) 更快.
- 神经退行过程的差异可能是这种临床分歧的基础.
- 大脑年龄估计提供了一种新的方法来量化神经退行变化.
研究的目的:
- 为了研究PD-CI和PD-NCI患者之间的大脑年龄差异.
- 为了确定这些大脑年龄差异的临床意义.
- 探索大脑年龄指标作为PD-CI生物标志物的实用性.
主要方法:
- 在94名参与者 (PD-CI,PD-NCI和对照组) 中,利用基于灰质 (GM) 和白质 (WM) 特征的预测年龄差异 (PAD).
- 在调整了人口因素后,在不同组中比较了GM-PAD和WM-PAD.
- 分析了PAD,认知分数 (MMSE,MoCA,逻辑记忆) 和临床尺度 (UPDRS第二部分) 之间的相关性.
主要成果:
- 与PD-NCI患者和对照患者相比,PD-CI患者的GM-PAD和WM-PAD显著增加.
- 在PD患者中,GM-PAD与认知评分 (MMSE,MoCA) 负相关,与UPDRS Part II正相关.
- 在PD患者中,WM-PAD与逻辑记忆表现负相关.
- 大脑年龄指标改善了PD-CI和PD-NCI之间的分类准确性.
结论:
- 与PD-NCI相比,患有PD-CI的患者表现出先进的大脑衰老.
- 在PD-CI中,晚期大脑衰老与认知功能受损和疾病严重程度有关.
- 神经成像衍生的大脑年龄指标显示出潜在的生物标志物用于识别和表征PD-CI.
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