相关实验视频

Updated: Jun 30, 2025

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model

Published on: January 12, 2022

YY1乳化通过通过炎症基因增强微质功能,加剧自身免疫性尿道炎

Jiaxing Huang¹, Xiaotang Wang¹, Na Li²

¹Chongqing Key Laboratory of Ophthalmology, Chongqing Eye Institute; Chongqing Branch of National Clinical Research Center for Ocular Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

|March 17, 2024

概括

视网膜微质中阴阳1 (YY1) 的乳化通过增加炎症和细胞增殖驱动自身免疫性脑膜炎. 针对这种乳化途径为这种眼睛疾病提供了潜在的治疗策略.

科学领域:

免疫学免疫学免疫学
神经科学是一个神经科学.
眼科医生眼科眼科

背景情况:

视网膜中的激活的微质细胞在自身免疫性脑膜炎中起着关键作用.
阴阳1 (YY1) 是一种转录因子,涉及炎症和免疫疾病.

研究的目的:

在实验性自身免疫性脑膜炎 (EAU) 期间,研究YY1乳化在视网膜微中的作用.
阐明YY1乳化影响微质激活和炎症的机制.
为了确定EAU的潜在治疗目标.

主要方法:

在目标和标记 (CUT&Tag) 下的裂纹分析以识别YY1调节的基因.
在体外和体内实验,以评估抑制乳的效果.
评估微质激活,增殖,迁移和炎症基因表达.

主要成果:

在EAU小鼠的视网膜微质中观察到YY1乳化增加.
YY1乳化增强了微质激活,增殖和迁移.
抑制乳化或p300 (乳化写字器) 抑制了微质激活和减弱了EAU.
YY1乳化调节炎症基因,包括STAT3,CCL5,IRF1,IDO1和SEMA4D. 这两种基因都具有重要作用.

结论:

YY1乳化通过增加炎症性细胞因子分泌和增强细胞迁移和增殖,促进自身免疫性脑膜炎的微质功能障碍.
向乳酸/p300/YY1乳化/炎症基因轴为自身免疫性脑膜炎提供了一个有前途的治疗策略.

关键词:

阴阳 1 阴阳 1 自身免疫性脑膜炎的发生这是一种炎症炎症炎症炎症.乳化乳化乳化微质细胞中的微质细胞

更多相关视频

Induction of Ocular Surface Inflammation and Collection of Involved Tissues

Induction of Ocular Surface Inflammation and Collection of Involved Tissues

Published on: August 4, 2022

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates

Published on: January 30, 2014

相关概念视频

Autoimmune Disorders

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...

T Cell Types and Functions

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...