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狗狗的长度抗微生物敏感性趋势斯塔菲洛哥克菌伪中间体

Caroline Calabro¹, Ritwik Sadhu², Yuchen Xu²

¹Department of Public and Ecosystem Health, Cornell University College of Veterinary Medicine, Ithaca, NY, USA; Department of Clinical Sciences, Cornell University College of Veterinary Medicine, Ithaca, NY, USA.

Preventive veterinary medicine

|March 17, 2024

概括

Staphylococcus pseudintermedius中的抗微生物耐药性正在增加,特别是在耐甲林菌株 (MRSP) 中. 这一趋势需要改善抗微生物药物管理和监测,以保持犬类皮肤炎治疗的有效性.

科学领域:

兽医微生物学兽医微生物学
抗微生物耐药性研究研究
狗的健康狗的健康

背景情况:

伪中间体葡萄球菌 (Staphylococcus pseudintermedius) 是狗皮肤炎的一个关键病原体.
这种物种的抗菌素耐药性 (AMR) 带来了治疗挑战和潜在的动物感染风险.
在S. pseudintermedius中AMR的长期时间趋势没有得到充分的记录.

研究的目的:

从狗皮肤样本评估S. pseudintermedius的抗微生物耐药性流行率和最小抑制度 (MIC) 趋势.
在14年期间 (2007-2020年) 评估耐药性模式的时间变化.
为了比较分析AMR趋势的不同统计方法.

主要方法:

从狗皮肤样本中分析了1804 S. pseudintermedius的分离物.
对23种抗微生物药物的耐药性流行率和MIC的评估.
使用Cochran-Armitage测试,logrank测试和加速失效时间 (AFT) 模型与非线性预测器 (splines) 的应用.

主要成果:

多种药物耐药性普遍存在 (47%),对β-乳糖胺,氨基醇,诺基诺,胺素,宏类/林科萨米德,四环素和三甲-硫甲醇的耐药性较高.
甲素耐药的S. pseudintermedius (MRSP) 占38%的分离物,对大多数测试的抗微生物药物表现出更高的耐药性.
AFT模型显示,几种抗生素类别的MIC随着时间的推移而增加,与多西环林耐药性下降形成鲜明对比. 发现了基于流行率的方法错过的非线性趋势.

结论:

增加S. pseudintermedius的抗菌素耐药性,特别是MRSP,是治疗犬类皮肤炎的重要问题.
具有非线性预测器的加速失效时间 (AFT) 模型为AMR监测提供了一个有价值的,独立于断点的工具.
合理的处方实践和加强的AMR监测对于保持治疗疗效至关重要.

关键词:

抗微生物耐药性抗微生物耐药性狗的皮肤炎是狗的皮肤炎.斯塔菲洛科克菌伪中间体.

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