在侵入性机械通风过程中用于长期镇静的酸和酸相比:试点随机临床试验
Xuehui Gao1, Xiaobo Yang1, Yun Tang1
1Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Journal of clinical anesthesia
|March 17, 2024
概括
在ICU中长期镇静时,二提供了与二相似的疗效和安全性. 这项研究发现,这两种镇静剂的镇静效果相似,不良事件发生率低,包括高甘油三血症.
科学领域:
- 麻醉学 麻醉学
- 临界护理医学 临界护理医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 普罗波是一种广泛使用的麻醉剂,但其脂质乳液配方具有细菌污染和高甘油三血症等风险.
- 甲二,甲的水溶性前药物,是为了减轻这些风险而开发的.
- 在大规模试验之前,研究二在长期重症监护室 (ICU) 镇静中的功效至关重要.
研究的目的:
- 评估与相比,propofol二的可行性,初始疗效和安全性,用于ICU患者的长期,轻度至中度镇静.
- 使用里士满兴奋和镇静量表 (RASS) 评估镇静的有效性,并监测不良事件.
主要方法:
- 进行了一个单一的,前性的,未盲目的,随机的,并行组临床试验.
- 60名需要机械通风24小时以上的成年患者被随机分配到酸或酸组.
- 连续输注进行,目标RASS得分为-3至0,主要结果是没有救援的目标镇静范围内的时间.
主要成果:
- 和都在目标RASS范围内的时间中位数达到相同的百分比 (83.33%).
- 76.7%的佛索普罗福尔组和90.0%的普罗福尔组报告了不良事件,其中心动减速和低血压是最常见的.
- 过高甘油三血症发生在10%的益醇组,而在益醇组为30%;酸盐水平仍然很低,在各组之间相似.
结论:
- 二 (fospropofol disodium) 证明了作为一种镇静剂的可行性,有效性和安全性,用于需要长期机械通风的患者.
- 这项研究支持二作为醇的可行替代品,可能提供更好的安全概况,关于高甘油三血症.
- 需要进一步的大规模随机试验来证实这些发现.
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