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Updated: Jun 30, 2025

Establishing a Device for Sleep Deprivation in Mice
Published on: September 22, 2023
睡眠不足改变了休息的人类大脑的频率特定的功能组织
Zhiguo Luo1, Erwei Yin2, Ye Yan2
1Defense Innovation Institute, Academy of Military Sciences (AMS), Beijing 100071, China; Intelligent Game and Decision Laboratory, Beijing 100071, China; Tianjin Artificial Intelligence Innovation Center (TAIIC), Tianjin 300450, China; College of Intelligence Science and Technology, National University of Defense Technology, Changsha, Hunan 410073, China.
睡眠不足改变了大脑网络的拓结构. 功能连接的变化,特别是在线圈-操作和默认模式网络,是频率依赖,影响信息交换.
科学领域:
- 神经科学是一个神经科学.
- 脑部成像 脑部成像
- 网络科学 网络科学
背景情况:
- 休息状态功能磁共振成像 (rs-fMRI) 研究已经探索睡眠剥夺 (SD) 后的时间连接变化.
- 然而,睡眠剥夺功能网络的频率特定拓性质仍然不清楚.
研究的目的:
- 为了研究经过36小时的SD后,大脑网络的频率特定的光谱连接变化和拓性质.
- 为了确定最受SD影响的频段和大脑网络.
主要方法:
- 37名健康男性在休息时 (RW) 和36小时SD后接受了rs-fMRI.
- 使用多变量模式分析 (SVM) 和图形理论分析分析了特定频率的光谱连接性 (0.01-0.08 Hz).
主要成果:
- 在RW和SD状态之间的分类实现了74.29%-84.29%的准确性,最低和最高频段显示出更高的辨别能力.
- SD增加了涉及 cingulo-opercular 网络的连接,并减少了涉及默认模式网络的连接.
- 在SD状态下观察到低频模块化和高频全局效率的减少,小脑和 cingulo-opercular 网络枢纽显示出高的区分能力.
结论:
- 睡眠不足对功能网络拓和信息交换效率有频率相关的影响.
- 这些发现为SD对人类大脑功能的影响提供了新的见解.
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