在移植接受者中缺铁,贫血和患者报告的结果
Daan Kremer1, Tim J Knobbe1, Joanna Sophia J Vinke1
1Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
概括
铁缺乏症在移植受体 (KTRs) 中经常被忽视,显著加重疲劳,注意力集中和生活质量. 解决铁缺乏症可能会改善KTRs中患者报告的结果.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 移植 移植 移植 移植
- 精神病体医学是一种精神病体医学.
背景情况:
- 移植接受者 (KTRs) 经常报告健康状况比一般人群更差,包括疲劳,焦虑和生活质量下降.
- 虽然贫血是一个公认的问题,但铁缺乏对KTR的影响不太清楚.
- 缺铁可能会对患者报告的结局产生负面影响,而这与贫血无关.
研究的目的:
- 调查移植患者的铁缺乏,贫血和患者报告的结果之间的关联.
- 为了确定铁缺乏是否影响KTRs的疲劳,集中度,幸福感,焦虑,抑郁症状和与健康有关的生活质量 (HRQoL).
主要方法:
- 分析了814名门诊患者的KTR队列.
- 铁缺乏症被定义为转林和率<20%和费里丁<100μg/L.
- 贫血是根据世界卫生组织的标准定义的.
- 使用线性和逻辑回归模型来评估关联,并对混因素进行调整.
主要成果:
- 28%的KTR患有缺铁,29%患有贫血.
- 缺铁,而不是贫血,与增加的疲劳,更差的注意力集中,更低的幸福感,更多的焦虑,抑郁症状和减少HRQoL显著相关.
- 缺铁与53%更高的严重疲劳风险,100%更高的严重抑郁症状风险和51%更高的病假/失业风险相关.
结论:
- 缺铁是普遍存在的,并显著影响KTRs患者报告的结果.
- 纠正缺铁可能会改善这种人群的疲劳,心理健康和HRQoL.
- 需要进一步的临床试验来证实KTRs铁缺乏症治疗的好处.
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